When it comes to jobs and careers, that especially holds true. The goal should never be to get a job, but the right job. To be clear, the right job is the job that combines what you do with who you are. The job that calls upon your superpowers.
The job you may not be qualified for.
We tend to view our professional selves in terms of our qualifications. The problem is that our qualifications are limited, which means that we carry a limited view of our abilities and the roles that we can play. When a job comes along that most people feel is "out of reach" for them, they simply don't apply.
They are afraid to take a chance.
Someone with better qualifications may get the job, but you may be better for the job. There's a difference. People are not human resumes. By (courageously) applying for the job that you think you have no chance of getting, you do run the risk of rejection, but you also (potentially) win the opportunity to present your case as to why you are the best person for the job, even though you may not be the best qualified on paper.